Skin Cancer


Efudix is a cream that is applied to the skin to treat certain types of skin cancers such as actinic keratoses (sun spots) or intraepithelial carcinoma (IEC).

Fluorouracil is the active ingredient in Efudix. It is a type of anti-cancer medications that works by destroying the precancerous and cancerous cells.

What you need to know about

  • How to use Efudix: Wash the area to be treated with warm water and pat dry. Allow the skin to dry completely. Apply a thin film of Efudix to the affected skin using either cotton bud or rubber glove, or use your finger tip and wash your hands thoroughly afterwards. Be careful not to get Efudix in the eyes, eyelids, nostrils or lips. Do not apply to broken skin or infected areas. The total area of skin treated with Efudix should not exceed 500 cm2 at a time. Large areas should be treated in sections. Try to use Efudix at the same time each day to have the best effect. While undergoing Efudix treatment, your skin can become very light sensitive. Limit your sun exposure during and immediately following treatment. Apply sunscreen every day before going outdoors (but don’t apply directly on the treatment area), and wear appropriate clothes (long sleeves, trousers and hat).
  • How long to use Efudix: In general, Efudix are often applied once to twice a day for 4-6 weeks. Follow the advice from your Dermatologist on how often and how long to use Efudix for.
  • What to expect: Efudix cream may result in mild to severe burning sensation. Redness and scaling of the affected area in 3 – 5 days. Blistering, peeling and cracking within 11 – 14 days and occasional open sores and some discomfort. Treated skin will then flake away. These side effects are signs that Efudix is working. They are usually short-lived and skin is expected to heal without much scarring after treatment has stopped.

Expected reactions

Excessive inflammatory reactions

Possible Complications

Some degree of pain, erosion, itchiness, crusting and dermatitis are expected during treatment.

Complications may occasionally occur that you should seek medical attention for:

  • Excessive local inflammation resulting in ulcers, blistering and swelling
  • Hypersensitivity reactions
  • Systemic symptoms such as fever, nausea, diarrhea, mouth ulcers, flu like symptoms
  • Abnormal blood tests – raised or low white cell count
  • Contact dermatitis
  • Secondary infection from bacteria getting through skin erosions

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